After nine-year-old Melmo loses her mother in a car accident, she is left to care for her two younger brothers, a task far beyond her age or means. However, in the midst of her grieving, Melmo is visited by the ghost of her deceased mother who gives her a bottle of miraculous candy, capable of transforming her into either an adult (blue candy) or an infant (red candy). A combination of the two can reduce her to a fetus and then change her into any animal she imagines. Drawing on a seemingly inexhaustable supply, Melmo uses her candies to solve the various problems thrown her way, aided by her younger brother Toto (who accidentally morphs into a frog in episode 7) and her cantankerous mentor, Dr Nosehairs.